The recently completed Science and Engineering Complex is the largest and most ambitious project ever undertaken by Harvard University. The 550,000 sf facility houses the School of Engineering and Applied Science (SEAS) along with other research programs, and is designed to be the premier facility of its type in the world. The building combines wet research labs, teaching labs, dry labs, classrooms/lecture halls, a dining/kitchen facility, vivarium and various support spaces, all built around a massive eight story atrium. The project employed a highly integrated design process to satisfy the aggressive project goals developed by Harvard and the Design Team. Among these goals were achieving the highest possible level of energy efficiency while providing a healthy environment for occupants and exceptional resiliency. This presentation will highlight the design process undertaken and the resulting architectural and mechanical/ electrical design strategies used to satisfy these goals. Strategies to be discussed include envelope and shading screen optimization, occupant comfort analysis, laboratory ventilation optimization, radiant heating and cooling systems, natural/mechanically induced ventilation, and high efficiency heat recovery with indirect evaporative cooling. Resiliency/flood mitigation measures and the elaborate water recycling/re-use system will be reviewed as well. The project is has achieved LEED Platinum certification with a projected EUI of 86 along with LBC Materials Petal certification.